There are rivers where fishing with nymphs is common. In fact is so popular that you will see very rare a dry fly fisherman. Hot spots are super effective but I noticed that orange and red are not so good like was 5-6 years ago. Also gold tungsten beads are not effective like silver or copper. Even more, on rivers with high fishing pressure black nickel or black beads work better.
For a year ago I started to avoid orange and red as hot spots and I replaced them with mylar or just simple white dubb on some flies. I was very pleased with these colors so here are 2 trout nymphs that work for me very well: